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The Duomo: Exit at Duomo Station for Milan’s most famous cathedral. Construction on this marble masterpiece began in 1386. Tip: Get there before 5 PM and head up to the roof for a breathtaking view.

Santa Maria delle Grazie: Exit at Cardona for this church which houses Da Vinci’s Last Supper. Tickets are best bought months ahead, but savvy travelers know to arrive early because canceled reservations are sold daily, starting at 8:15 AM.

La Scala Theater: Exit Duomo Station to see what might be the world’s most famous opera house. Opened in 1798 and remodeled in the last decade, La Scala was home to luminaries like Giuseppe Verdi and Arturo Toscanini.

Meazza Stadium: Exit at Lotto Station during football (that’s soccer for you Americans) season and catch a match between the excellent AC Milan or FC Internazionale and a rival club from Italy’s Serie A.